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Gludex IM/IV Injection
Dexamethasone Sodium Phosphate is used for Inflammatory conditions, Autoimmune conditions, Allergic or inflammatory conditions, Covid-19.
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✅ Description:
Dexamethasone 5mg/ml-
- Allergic states: Control of severe allergic conditions in asthma, dermatitis, drug reactions, allergic rhinitis, and serum sickness.
- Collagen disease: e.g., lupus erythematosus, rheumatoid arthritis.
- Dermatologic diseases: Bullous dermatitis, erythroderma, pemphigus, Stevens-Johnson syndrome.
- Endocrine disorders: Adrenocortical insufficiency, congenital adrenal hyperplasia, hypercalcemia in cancer, nonsuppurative thyroiditis.
- Gastrointestinal diseases: Regional enteritis, ulcerative colitis.
- Hematologic disorders: Hemolytic anemia, hypoplastic anemia, thrombocytopenic purpura.
- Neoplastic diseases: Leukemias, lymphomas.
- Nervous system: Acute exacerbations of multiple sclerosis, cerebral edema.
- Ophthalmic diseases: Temporal arteritis, uveitis, and ocular inflammatory conditions.
- Renal diseases: Inducing diuresis or remission of proteinuria in nephrotic syndrome.
- Respiratory diseases: Pulmonary tuberculosis, eosinophilic pneumonia, sarcoidosis.
- Rheumatic disorders: Short-term therapy for gouty arthritis, rheumatic carditis, arthritis, dermatomyositis, polymyositis, lupus erythematosus.
- Miscellaneous: Diagnostic testing of adrenocortical hyperfunction, trichinosis with neurologic involvement, tuberculous meningitis.
Safety Advices
Alcohol
CAUTION
Interaction with alcohol is unknown.
Pregnancy
CONSULT YOUR DOCTOR
- Inform your doctor if pregnant.
- Prescription based on benefits vs. risks.
Breastfeeding
CONSULT YOUR DOCTOR
- Inform your doctor if nursing.
- Prescription based on benefits vs. risks.
Driving
CAUTION
- May reduce mental awareness.
- Exercise caution.
Kidney
CAUTION
- Inform your doctor.
- Discuss your kidney condition with your doctor.
Liver
CAUTION
- Inform your doctor.
- Discuss your liver condition with your doctor.
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✔️ Uses of Gludex IM/IV injection
- Allergic conditions
- Severe allergic reactions
- Asthma
- Cancer
- Rheumatic disorder
- Skin disorders
- Eye disorders
- Nephrotic syndrome
✔️ How does Gludex IM/IV injection work?
Gludex IM/IV is a steroid that works by blocking the production of certain chemical messengers in the body that cause inflammation (redness and swelling) and allergies.
✔️ Side Effects of Gludex IM/IV injection
Various adverse reactions are associated with prolonged use, including endocrine/metabolic, fluid/electrolyte disturbances, musculoskeletal effects, gastrointestinal effects, dermatological effects, CNS effects, ophthalmic effects, and immunosuppressive effects.
✔️ Quick Suggestions:
- Do not use it more often or for longer than advised by your doctor.
- Dexamethasone Injection may affect various laboratory tests.
- Dexamethasone can make it harder for you to fight off infections. Notify your doctor if you have any signs of infection such as a fever or sore throat.
✔️ Indications
- Severe allergic conditions
- Collagen diseases
- Pulmonary disorders
- Blood disorders
- Rheumatic diseases
- Skin diseases
- Gastrointestinal disorders
- Oedema
- Eye disorders
- Neoplastic states
- Endocrine disorders
- Preoperative and postoperative support
- Treatment of COVID-19 in certain patients
✔️ Pharmacology
Dexamethasone is a synthetic glucocorticoid that decreases inflammation, inhibiting leukocyte migration and reducing capillary permeability. It suppresses the normal immune response.
✔️ Dosage & Administration of Gludex IM/IV injection
Given intravenously (IV), intramuscularly (IM), or locally. The dosage depends on the severity, usually 0.05-0.20 mg/kg for systemic therapy in adults.
✔️ Interaction
- Diuretics and/or cardiac glycosides.
- Antidiabetics.
- Non-steroidal anti-inflammatory drugs.
- Oral anticoagulants.
- Less effective with liver enzyme-inducing drugs.
✔️ Contraindications
- Gastric and duodenal ulcers.
- Systemic and ophthalmic fungal infections.
- Viral infections.
- Glaucoma.
- Hypersensitivity to corticosteroids.
✔️ Pregnancy & Lactation
Category C. Use during pregnancy only if benefits justify risks. Glucocorticoids appear in breast milk.
✔️ Precautions & Warnings
- Use the lowest possible dose.
- Caution in cardiovascular, endocrine, gastrointestinal, musculoskeletal, and neuropsychiatric conditions.
- Pediatric patients should be titrated to the lowest effective dose.
✔️ Storage Conditions
Below 30°C, protected from light. Do not freeze. Keep out of reach of children.
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